2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N9535A
    (R)-tert-OMe-byakangelicin 89560-97-4 98%
    (R)-tert-OMe-byakangelicin is a kind of furanocoumarin, which has inhibitory activity to liver drug metabolizing enzyme (DME) activity. (R)-tert-OMe-byakangelicin can be isolated from immature fruits of Angelica sinensis.
    (R)-tert-OMe-byakangelicin
  • HY-NP0207
    Vomitoxin-BSA 98%
    Vomitoxin-BSA (DON-BSA) is an artificial antigen containing Deoxynivalenol (Vomitoxin) (HY-N6684) and BSA. Deoxynivalenol is one of the most important mycotoxins related to food chains. Vomitoxin-BSA can be used to generate anti-Deoxynivalenol monoclonal antibodies.
    Vomitoxin-BSA
  • HY-P0014A
    Liraglutide acetate 1997361-86-0 98%
    Liraglutide acetate is the acetate form of Liraglutide (HY-P0014), a glucagon-like peptide-1 (GLP-1) receptor agonist studied in type 2 diabetes.
    Liraglutide acetate
  • HY-P0058A
    Pramlintide TFA 98%
    Pramlintide TFA is a polypeptide analogue of human amylin. Pramlintide TFA, an antidiabetic agent, is antineoplastic in colorectal cancer.
    Pramlintide TFA
  • HY-P0080A
    Novokinin TFA 1262750-59-3 98%
    Novokinin TFA is a peptide agonist of the angiotensin AT2 receptor.
    Novokinin TFA
  • HY-P0084A
    Cyclic somatostatin acetate 54472-66-1 98%
    Cyclic somatostatin (SRIF-14) acetate is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin acetate is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin acetate inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin acetate can be used for the research of cardiovascular disease.
    Cyclic somatostatin acetate
  • HY-P0165B
    Taspoglutide acetate 1022150-16-8 98%
    Taspoglutide (R1583) acetate is an agonist of the glucagon-like peptide 1 receptor (GLP-1R) with an Ki value of 1.1 nM. Taspoglutide acetate induces cAMP accumulation in CHO-K1 cells expressing human GLP-1R (EC50 = 0.06 nM). Taspoglutide acetate decreases blood levels of glucose and increases blood levels of insulin in a glucose tolerance test in Zucker diabetic obese rats. Taspoglutide acetate reduces blood levels of gastric inhibitory polypeptide (GIP), plasma levels of triglycerides, and body weight in the same model.
    Taspoglutide acetate
  • HY-P0179A
    β-Casomorphin, bovine TFA 98%
    β-Casomorphin, bovine TFA (β-Casomorphin-7 (bovine) TFA) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay.
    β-Casomorphin, bovine TFA
  • HY-P0198B
    [D-Arg25]-Neuropeptide Y (human) 98%
    [D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) is a Y1 receptor selective agonist. Neuropeptide Y (human) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.
    [D-Arg25]-Neuropeptide Y (human)
  • HY-P0212A
    Neuropeptide Y, porcine TFA 98%
    Neuropeptide Y, porcine TFA, a peptide in porcine brain, is capable of inhibiting secretin-stimulated pancreatic secretion.
    Neuropeptide Y, porcine TFA
  • HY-P0248F
    Kemptide, 5-FAM labeled 1161072-61-2 98%
    Kemptide, 5-FAM labeled is a 5-FAM labeled Kemptide (HY-P0248). Kemptide is a phosphate acceptor peptide that serves as a synthetic substrate for PKA (Km = 16 μM). The corresponding fluorescent and biotinylated peptides are also proven to be good substrates for PKA.
    Kemptide, 5-FAM labeled
  • HY-P0253A
    Xenopsin TFA 98%
    Xenopsin TFA, a neurotensin-like octapeptide from Xenopus laevis skin. Xenopsin TFA is an inhibitor of Tetragastrin stimulated gastric acid secretion.
    Xenopsin TFA
  • HY-P0267A
    Melanotan (MT)-II acetate 1036322-26-5 98%
    Melanotan (MT)-II acetate is a melanocortin receptor agonist that crosses the blood-brain barrier. Melanotan (MT)-II acetate activates melanocortin receptor 3 and melanocortin receptor 4, and stimulates the release of central endogenous oxytocin. Melanotan (MT)-II acetate reverses recognition memory impairment, increased anxiety levels and reduced exploratory tendency in zebrafish exposed to short-term high-fat diet. Melanotan (MT)-II acetate improves impaired social behavior indicators in mouse models of autism spectrum disorder. Melanotan (MT)-II acetate induces weight loss, reduces food intake and exerts anorectic effects. Melanotan (MT)-II acetate increases intracavernous pressure and erectile activity in brown rats. Melanotan (MT)-II acetate can be used in studies related to memory impairment, anxiety, reduced exploratory behavior, autism spectrum disorder, obesity and erectile dysfunction.
    Melanotan (MT)-II acetate
  • HY-P0322A
    GRGDSPK TFA 98%
    GRGDSPK TFA (EMD 56574 TFA) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK TFA is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK TFA is used to study the role of integrins in bone formation and resorption.
    GRGDSPK TFA
  • HY-P10041
    Obestatin(11-23)mouse, rat 938193-98-7 98%
    Obestatin(11-23)mouse, rat is a polypeptide involved in regulating energy balance and inhibiting eating. Obestatin(11-23)mouse, rat causes reduced food intake, body weight, and jejunal contractions in rodents.
    Obestatin(11-23)mouse, rat
  • HY-P10046
    [Deamino-Pen1,Val4,D-Arg8]-vasopressin 64158-84-5 98%
    [Deamino-Pen1,Val4,D-Arg8]-vasopressin (AVP-A) is an arginine-vasopressin (AVP) antagonist. AVP-A can significantly lower plasma aldosterone concentration in rats. AVP-A can be used for the research of the growth and steroidogenic capacity of rat adrenal zona glomerulosa.
    [Deamino-Pen1,Val4,D-Arg8]-vasopressin
  • HY-P10053
    sPLA2-IIA Inhibitor 236394-37-9 98%
    sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids.
    sPLA2-IIA Inhibitor
  • HY-P10062
    Hylambatin 80890-46-6 98%
    Hylambatin, a tachykinin, increases both plasma glucose and plasma insulin, whereas the secretion of glucagon was not affected. Hylambatin can be used in diabetes research.
    Hylambatin
  • HY-P10063
    Cionin 126985-56-6 98%
    Cionin is a disulfotyrosyl hybrid of cholecystokinin and gastrin.
    Cionin
  • HY-P10076
    TAT-JBD20 98%
    TAT-JBD20 (L-HIV-TAT(48–57)-PP-JBD20) is a JNK peptide inhibitor. TAT-JBD20 can be used for research of diabetes.
    TAT-JBD20
Cat. No. Product Name / Synonyms Application Reactivity